反应详情

A suspension of 2-[6-(1-benzhydryl-3-methyl-azetidin-3-yloxy)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-propionic acid ethyl ester (0.300 g, 0.070 mmol) and Pd(OH)2/C (10%, 0.170 g) in EtOH (15 mL) was stirred under H2 (50 psi) at ambient temperature overnight. The reaction mixture was filtered and the filtrate was evaporated in vacuo to give 2-[6-(3-methyl-azetidin-3-yloxy)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-propionic acid ethyl ester (0.250 g, crude) as an oil, which was used in the next step directly. LC/MS (Table 1, Method 2) Rt=0.806 min.; MS m/z: 335 [M+H]+.

1. filtrationThe reaction mixture was filtered
2. customthe filtrate was evaporated in vacuo