反应详情

A suspension of 2-[7-fluoro-6-(1-benzhydryl-3-methyl-azetidin-3-yloxy)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-propionic acid ethyl ester (0.280 g, 0.540 mmol) and Pd(OH)2/C (10%, 0.140 g, 0.1 mmol) in EtOH (15 mL) was stirred under H2 (50 psi) at ambient temperature overnight. The reaction mixture was filtered and the filtrate was evaporated in vacuo to give 2-[7-fluoro-6-(3-methyl-azetidin-3-yloxy)-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl]-propionic acid ethyl ester (0.275 g, crude) as an oil, which was used in the next step directly. LC/MS (Table 1, Method 3) Rt=1.026 min.; MS m/z: 353 [M+H]+.

1. filtrationThe reaction mixture was filtered
2. customthe filtrate was evaporated in vacuo