反应详情

2-(5-Trifluoromethyl-pyridin-2-yl)-benzoic acid isopropyl ester was dissolved in 10 ml of a 3:1:1 mixture of tetrahydrofuran-methanol-water, and lithium hydroxide monohydrate (161 mg, 3.84 mmol) was added. After stirring for 3 h at room temperature, the volatiles were removed under vacuum and 5 ml of water were added to the mixture, which was brought to pH 6 with 1N HCl. The resulting slurry was extracted with ethyl acetate, the combined organic layers were dried (magnesium sulfate), filtered and concentrated under vacuum to provide the title compound.

1. additionwas added
2. customthe volatiles were removed under vacuum and 5 ml of water
3. additionwere added to the mixture, which
4. extractionThe resulting slurry was extracted with ethyl acetate
5. dry with materialthe combined organic layers were dried (magnesium sulfate)
6. filtrationfiltered
7. concentrationconcentrated under vacuum