反应详情

7-[2-(5-Trifluoromethyl-pyridin-2-yl)-benzoylamino]-quinoline-3-carboxylic acid ethyl ester (180 mg, 0.387 mmol) was dissolved in 5 ml of a 3:1:1 mixture of tetrahydrofuran-methanol-water, and lithium hydroxide monohydrate (50 mg, 1.16 mmol) was added. After 18 h at reflux, the volatiles were removed under vacuum and water was added to the mixture, which was acidified with 1N HCl, extracted with ethyl acetate. The combined organic layers were dried (magnesium sulfate), filtered and concentrated under vacuum to provide the title compound.

1. additionwas added
2. temperatureAfter 18 h at reflux
3. customthe volatiles were removed under vacuum and water
4. additionwas added to the mixture, which
5. extractionextracted with ethyl acetate
6. dry with materialThe combined organic layers were dried (magnesium sulfate)
7. filtrationfiltered
8. concentrationconcentrated under vacuum