HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 519420Generated: October 25, 2026
N-bromobutanimide → 9-Bromobenzimidazo[2,1-a]isoquinoline
https://huagongshe.com/reaction/519420
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Benzimidazo(2,1-a)isoquinoline | HCID 612818 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 9-Bromobenzimidazo[2,1-a]isoquinoline | HCID 71077841 | — |
Reaction Steps
32.6 g (183 mmol) of NBS are added to a solution of 40 g (183 mmol) of benzimidazo[2,1-a]isoquinoline in 500 ml of THF, and the mixture is stirred at 60° C. for 4 h. The solution is subsequently stirred at room temperature overnight, the solid is filtered off with suction, washed with ethanol and dried. Yield: 51.3 g (181 mmol), 98%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09118022B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-5233474b9efa47b1b1f59595aa28299a |
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| Source note | uspto-grants-2015_08 |
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