反应详情

温度

60 °C

32.6 g (183 mmol) of NBS are added to a solution of 40 g (183 mmol) of benzimidazo[2,1-a]isoquinoline in 500 ml of THF, and the mixture is stirred at 60° C. for 4 h. The solution is subsequently stirred at room temperature overnight, the solid is filtered off with suction, washed with ethanol and dried. Yield: 51.3 g (181 mmol), 98%.

1. stirringThe solution is subsequently stirred at room temperature overnight
2. filtrationthe solid is filtered off with suction
3. washwashed with ethanol
4. customdried