反应详情

A solution of 1H-1,2,4-triazol-3-amine (1.5 g) and methyl 2-[(2′-cyanobiphenyl-4-yl)methyl]-3-oxoheptanoate (7.1 g) in 1,2,4-trichlorobenzene (70 mL) was stirred at 190° C. for 6 hr. After evaporation of the solvent under reduced pressure, ethyl acetate was added to the obtained residue. The precipitated solid was collected by filtration to give the title compound as a colorless solid (3.6 g, 44%).

1. customAfter evaporation of the solvent under reduced pressure, ethyl acetate
2. additionwas added to the obtained residue
3. filtrationThe precipitated solid was collected by filtration