反应详情

温度

60 °C

To a nitrogen purged 3 liter 4-neck flask fitted with a condenser, mechanical stirrer, temperature probe, and connected to a 2M aqueous NaOH scrubber was added toluene (1 L), 4′-trifluoromethyl-biphenyl-2-carboxylic acid (250 g, 0.94 mol, 1 equiv), and DMF (5 mL). 4′-Trifluoromethyl-biphenyl-2-carboxylic acid can be obtained from Aldrich, Milwaukee, Wis. The solution was heated to 60° C. and thionyl chloride (110 mL, 1.5 mol, 1.6 equiv) was added at such a rate as to maintain the temperature below 65° C. The addition was complete after 30 minutes and the reaction was heated to reflux. After 4 hours, the heating was stopped and the reaction was allowed to stir overnight at room temperature. The reaction mixture was concentrated in vacuo and the residue was used in the next step without further purification. The material crystallized to a solid at room temperature.

1. customTo a nitrogen purged 3 liter 4-neck flask
2. customfitted with a condenser, mechanical stirrer
3. temperatureto maintain the temperature below 65° C
4. additionThe addition
5. temperaturethe reaction was heated to reflux
6. waitAfter 4 hours
7. concentrationThe reaction mixture was concentrated in vacuo
8. customthe residue was used in the next step without further purification
9. customThe material crystallized to a solid at room temperature