反应详情

To a 250 ml three-necked round-bottomed flask fitted with a reflux condenser, magnetic stirrer, internal thermometer, addition funnel, and argon inlet are added N-[2-((phenoxycarbonyl)oxy)ethyl]-N,N-dimethylamine (25.00 g, 0.120 mol), acetonitrile (100 ml), and phenyl chloroacetate (20.38 g, 0.120 mol) over 5 min. After addition is complete, the mixture is heated to reflux for 3 h. The cooled mixture is triturated with ether (500 ml). A white solid, 23.15 g (51%) is isolated to give 9.

1. customTo a 250 ml three-necked round-bottomed flask fitted with a reflux condenser, magnetic stirrer
2. additioninternal thermometer, addition funnel, and argon inlet
3. additionAfter addition
4. temperaturethe mixture is heated
5. temperatureto reflux for 3 h
6. customThe cooled mixture is triturated with ether (500 ml)
7. customA white solid, 23.15 g (51%) is isolated
8. customto give 9