HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl chloroacetate → N-2-((Phenoxycarbonyl)oxy)ethyl-N-((phenoxycarbonyl)methyl)-N,N-dimethyl-ammonium Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl chloroacetate | HCID 12108 | — |
| Reactant | Carbonic acid, 2-(dimethylamino)ethyl phenyl ester | HCID 11117296 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-2-((Phenoxycarbonyl)oxy)ethyl-N-((phenoxycarbonyl)methyl)-N,N-dimethyl-ammonium Chloride | HCID 19962803 | — |
Reaction Steps
To a 250 ml three-necked round-bottomed flask fitted with a reflux condenser, magnetic stirrer, internal thermometer, addition funnel, and argon inlet are added N-[2-((phenoxycarbonyl)oxy)ethyl]-N,N-dimethylamine (25.00 g, 0.120 mol), acetonitrile (100 ml), and phenyl chloroacetate (20.38 g, 0.120 mol) over 5 min. After addition is complete, the mixture is heated to reflux for 3 h. The cooled mixture is triturated with ether (500 ml). A white solid, 23.15 g (51%) is isolated to give 9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05616546 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-5aa905e6e57b49b59d89473150b79002 |
| Source note | uspto-grants-1997_04 |