Dichloromethane → HCID 178464398, compound

The Vilsmeier reagent was freshly prepared by the slow addition of phosphorus oxychloride (7.09 mL, 75.89 mmol, 1.2 eq) to a solution of N,N-ethylmethylformamide (6.61 g, 75.89 mmol, 1.2 eq) in dichloromethane (75 mL) at room temperature. After the addition was complete, the reaction mixture was stirred at room temperature for 1 h. The Vilsmeier reagent was then added drop wise over 40 min to a solution of 5-bromo-6-(cis-4-isopropylcyclohexoxy)-2-methyl-pyridin-3-amine (20.70 g, 63.24 mmol) in dichloromethane (225 mL) at room temperature under inert atmosphere (Ar). Stirring was continued for 1.5 h at room temperature. The reaction mixture was then quenched by the addition of water (100 mL) and the pH was adjusted to 14 by the addition of a 2.0 molar aqueous NaOH solution (80 mL). The phases were separated and the aqueous phase extracted with dichloromethane (2×100 mL). The organic layer was washed with brine (250 mL), dried over anhydrous Na2SO4 and filtered. The solvent was removed in vacuo to give a residue, which was purified by column chromatography (silica gel, heptane/ethyl acetate, v/v=1/0-4/1). Fractions containing the pure compound were collected and concentrated in vacuo to give the title compound (20.23 g, 81%) as a yellow oil.

1. additionAfter the addition
2. stirringStirring
3. waitwas continued for 1.5 h at room temperature
4. customThe reaction mixture was then quenched by the addition of water (100 mL)
5. additionthe pH was adjusted to 14 by the addition of a 2.0 molar aqueous NaOH solution (80 mL)
6. customThe phases were separated
7. extractionthe aqueous phase extracted with dichloromethane (2×100 mL)
8. washThe organic layer was washed with brine (250 mL)
9. dry with materialdried over anhydrous Na2SO4
10. filtrationfiltered
11. customThe solvent was removed in vacuo
12. customto give a residue, which
13. customwas purified by column chromatography (silica gel, heptane/ethyl acetate, v/v=1/0-4/1)
14. additionFractions containing the pure compound
15. customwere collected
16. concentrationconcentrated in vacuo

ORD record

ord-d6fd0cac9ae54ea8b729bb1bb578a550

Source dataset

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09326513B2