反应详情

温度

15 °C

A mixture of 3-(trifluoromethoxy)benzaldehyde 158a (10.0 g, 52.6 mmol) and ethyl 2-(triphenylphosphoranylidene)acetate 158b (27.5 g, 78.9 mmol) in DCM (200 mL) was stirred at 15° C. for 2 h. See FIG. 4. The resulting mixture was concentrated under reduced pressure, and the crude was purified by column chromatography on silica gel (ethyl acetate:petroleum ether=1:8) to afford ethyl 3-(3-(trifluoromethoxy)phenyl)acrylate 158c (12.0 g, 88%) as yellow oil.

1. concentrationThe resulting mixture was concentrated under reduced pressure
2. customthe crude was purified by column chromatography on silica gel (ethyl acetate:petroleum ether=1:8)