反应详情

To a solution of ethyl 4-methylenecyclohexanecarboxylate (2 g, 11.89 mmol) in ether (40 mL) was added LAH (0.5 g, 13.17 mmol) portionwise under N2. The reaction mixture was refluxed for 1 h and was quenched by addition of 1 mL of EtOAc carefully and refluxed for 10 min. The reaction mixture was cooled down and added 3 mL of 1 N NaOH and stirred for 5 min, filtered off the solid and washed with ether. The filtration was washed with water, brine, dried (MgSO4), and removed the solvent to afford (4-methylenecyclohexyl)methanol.

1. temperatureThe reaction mixture was refluxed for 1 h
2. customwas quenched by addition of 1 mL of EtOAc carefully
3. temperaturerefluxed for 10 min
4. temperatureThe reaction mixture was cooled down
5. additionadded 3 mL of 1 N NaOH
6. filtrationfiltered off the solid
7. washwashed with ether
8. filtrationThe filtration
9. washwas washed with water, brine
10. dry with materialdried (MgSO4)
11. customremoved the solvent