HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 520449Generated: October 29, 2026
Methylamine → N-(2-(2,4-dimethylthiazol-5-yl)-3-methyl-4-oxo-3,4-dihydroquinazolin-8-yl)pyrazine-2-carboxamide
https://huagongshe.com/reaction/520449
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | n-(2-(2,4-Dimethylthiazol-5-yl)-4-oxo-4h-benzo[d][1,3]oxazin-8-yl)pyrazine-2-carboxamide | HCID 58552812 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(2-(2,4-dimethylthiazol-5-yl)-3-methyl-4-oxo-3,4-dihydroquinazolin-8-yl)pyrazine-2-carboxamide | HCID 58552911 | 31% |
Reaction Steps
N-(2-(2,4-dimethylthiazol-5-yl)-4-oxo-4H-benzo[d][1,3]oxazin-8-yl)pyrazine-2-carboxamide 18 (100 mg, 0.26 mmol) was dissolved in 30 wt % solution of CH3NH2 in methanol (10 mL). The reaction mixture was heated at 80° C. for 12 h. The resulting precipitate was collected by filtration and rinsed with DME to give Compound 287 (32 mg, 31% yield). MS (ESI) calc. for C19H16F3N6O2S: 392.11. found: 393 [M+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09326986B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-9d96df94117341cca194a9a2038d82a0 |
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| Source note | uspto-grants-2016_05 |
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