HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 520460Generated: November 1, 2026
Hydrochloric Acid → 8-nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4(1H)-one
https://huagongshe.com/reaction/520460
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 8-nitro-4-oxo-2-(3-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3-carboxylate | HCID 58552877 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 8-nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4(1H)-one | HCID 58552922 | 86% |
Reaction Steps
A microwave vial was charged with of 8-nitro-4-oxo-2-(3-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3-carboxylate 36 (1.0 g, 2.46 mmol), dioxane (8 mL) and 1N HCl (4 mL). The reaction mixture was heated at 190° C. in the microwave for 50 min. The volatiles were evaporated and the residue dried under vacuum to give 37 (707 mg, 86% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09326986B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-811edc9f185f4f15bfb06c914ca0523f |
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| Source note | uspto-grants-2016_05 |
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