Hydrochloric Acid → HCID 58552814, compound

HRID 520467Notes

Reaction equation

HRID 520467 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[C:7]([C:12]([O:14]C)=[O:13])[CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)=[C:3]1C(OCC)=O.Cl>O1CCOCC1>[O:1]=[C:2]1[C:11]2[C:6](=[C:7]([C:12]([OH:14])=[O:13])[CH:8]=[CH:9][CH:10]=2)[NH:5][C:4]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:23])[F:24])[CH:17]=2)=[CH:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58552827HCID 58552827, compound

Product 1

HCID 58552814HCID 58552814, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
200 °C

Procedure

A 20 mL microwave vial was charged with 3-ethyl 8-methyl 4-oxo-2-(3-(trifluoromethyl)phenyl)-1,4-dihydroquinoline-3,8-dicarboxylate 43 (820 mg, 1.96 mmol), dioxane (8 mL) and 1N HCl (4 mL). The reaction mixture was heated in a microwave reactor at 200° C. for 25 min then concentrated to dryness in vacuo to give 44 (585 mg, 90% yield).

Workup

  1. concentrationthen concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-31477ecbbbe74976ab9bc325c16fa554
Source dataset
uspto-grants-2016_05
Patent number
US09326986B2

Reaction notes

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