HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(difluoromethyl)benzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-(difluoromethyl)benzoate | HCID 53435083 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(difluoromethyl)benzoic Acid | HCID 11499292 | 93% |
Reaction Steps
A mixture of methyl 2-(difluoromethyl)benzoate 52 (7 g, 38 mmol) and 10% aq. NaOH (100 mL) in MeOH (50 mL) was heated at reflux for 30 min. The pH was adjusted to 4 by the addition of 3N HCl. The resulting solid was collected by filtration, rinsed with H2O and dried to give 53 (6 g, 93% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09326986B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-3140ad8e436a4c06bf35fe024b0e4793 |
| Source note | uspto-grants-2016_05 |