反应详情

A mixture of methyl 2-(difluoromethyl)benzoate 52 (7 g, 38 mmol) and 10% aq. NaOH (100 mL) in MeOH (50 mL) was heated at reflux for 30 min. The pH was adjusted to 4 by the addition of 3N HCl. The resulting solid was collected by filtration, rinsed with H2O and dried to give 53 (6 g, 93% yield).

1. temperaturewas heated
2. temperatureat reflux for 30 min
3. filtrationThe resulting solid was collected by filtration
4. washrinsed with H2O
5. customdried