HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(Difluoromethyl)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(difluoromethyl)benzoic Acid | HCID 11499292 | — |
| Product | 2-(Difluoromethyl)benzoyl chloride | HCID 19035220 | — |
Reaction Steps
A solution of 2-(difluoromethyl)benzoic acid 53 (1.8 g, 10 mmol) in thionyl chloride (25 ml) was heated at reflux for 3 h. The reaction mixture was concentrated and dried under vacuum to give 54. The crude acid chloride was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09326986B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-4f58a0477fcc4daea6569d52c2054177 |
| Source note | uspto-grants-2016_05 |