참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | Methyl 6-(chloromethyl)pyridine-2-carboxylate | HCID 53404482 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 15123266 | HCID 15123266 | 67.4% |
반응 단계
K2CO3 (66 g, 0.48 mol) was added to a solution of methyl 6-(chloromethyl)picolinate 67 (45.0 g) and pyrrolidine 68 (34 g, 0.48 mol) in DMF (300 mL). The reaction mixture was heated at 80° C. for 12 h. H2O (300 mL) was added and the mixture was extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2SO4) and concentrated in vacuo to give 69 (36 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09326986B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_05 |
|---|
| ORD ID | ord-534ca0af16bb497b946d9c0a2804877b |
|---|
| 출처 메모 | uspto-grants-2016_05 |
|---|
