反应详情

温度

80 °C

K2CO3 (66 g, 0.48 mol) was added to a solution of methyl 6-(chloromethyl)picolinate 67 (45.0 g) and pyrrolidine 68 (34 g, 0.48 mol) in DMF (300 mL). The reaction mixture was heated at 80° C. for 12 h. H2O (300 mL) was added and the mixture was extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2SO4) and concentrated in vacuo to give 69 (36 g).

1. extractionthe mixture was extracted with EtOAc
2. washThe combined organic layers were washed with brine
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated in vacuo