HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(Chloromethyl)pyrimidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Chloroacrylonitrile | HCID 70198 | — |
| Reactant | HCID 86660238 | HCID 86660238 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(Chloromethyl)pyrimidin-4-amine | HCID 21298827 | 18% |
Reaction Steps
A solution of 2-chloroacetimidamide dihydrochloride 124 (250.0 g, 1.51 mol), 2-chloroacrylonitrile 125 (171 g, 1.95 mol) and triethylamine (490 g, 4.8 mol) in anhydrous ethanol (600 mL) was heated at reflux for 30 min. The solvent was removed in vacuo and the residue was purified by flash chromatography (dichloromethane:methanol=30:1) to give 126 (39.0 g, 18% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09326986B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-7e7013c991bb4919967696fcfb8fcfdf |
| Source note | uspto-grants-2016_05 |