Triethylamine → 2-(Chloromethyl)pyrimidin-4-amine

HRID 520499노트

반응식

HRID 520499 반응식
Cl.Cl.[Cl:3][CH2:4][C:5](=[NH:7])[NH2:6].Cl[C:9](=[CH2:12])[C:10]#[N:11].C(N(CC)CC)C>C(O)C>[Cl:3][CH2:4][C:5]1[N:6]=[C:10]([NH2:11])[CH:9]=[CH:12][N:7]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 701982-ChloroacrylonitrileHCID 86660238HCID 86660238, 화합물

생성물 1

HCID 212988272-(Chloromethyl)pyrimidin-4-amine수율 18%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of 2-chloroacetimidamide dihydrochloride 124 (250.0 g, 1.51 mol), 2-chloroacrylonitrile 125 (171 g, 1.95 mol) and triethylamine (490 g, 4.8 mol) in anhydrous ethanol (600 mL) was heated at reflux for 30 min. The solvent was removed in vacuo and the residue was purified by flash chromatography (dichloromethane:methanol=30:1) to give 126 (39.0 g, 18% yield).

후처리

  1. temperatureat reflux for 30 min
  2. customThe solvent was removed in vacuo
  3. customthe residue was purified by flash chromatography (dichloromethane:methanol=30:1)

출처 및 근거

ORD 기록
ord-7e7013c991bb4919967696fcfb8fcfdf
출처 데이터셋
uspto-grants-2016_05
특허 번호
US09326986B2

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