反应详情

2-Methyl-1,3-thiazole-4-carbonyl chloride (350 mg) in DCM (4 ml) was added dropwise to 1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-amine (300 mg) in DCM (15 ml) and pyridine (0.167 ml). The reaction was stirred at RT overnight. Saturated sodium bicarbonate (aq) (25 ml) was added and the reaction vigorously stirred for 15 min. The DCM was passed through a hydrophobic frit then evaporated to dryness. The residue was dissolved in DCM and purified on a silica cartridge, preconditioned with cyclohexane, washing with cyclohexane followed by elution with ether. The ether was evaporated to give title compound, 373 mg.

1. customthe reaction
2. stirringvigorously stirred for 15 min
3. customthen evaporated to dryness
4. dissolutionThe residue was dissolved in DCM
5. custompurified on a silica cartridge
6. washwashing with cyclohexane
7. washfollowed by elution with ether
8. customThe ether was evaporated