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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 520655Generated: October 31, 2026

Hydrochloric Acid → HCID 53233431, compound

https://huagongshe.com/reaction/520655

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantSodium HydroxideHCID 14798—
ReactantHCID 68226428HCID 68226428—
SolventIsopropanolHCID 3776—
ProductHCID 53233431HCID 53233431—

Reaction Conditions

Temperature70 °C

Reaction Steps

A solution of N-{1-(phenylsulfonyl)-6-[1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-indazol-4-yl}-2-furancarboxamide (80 mg) and 2M sodium hydroxide (2 ml) in IPA (4 ml) was stirred for 18 h at RT. The solution was heated at 70° C. for 1.5 h. The solution was cooled, neutralized with 2M HCl (aq) (2 ml) and purged with nitrogen to remove the IPA. The resulting solid was collected by filtration and dried in vacuo at 50° C. to give title compound, 30 mg.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09326987B2
Source datasetuspto-grants-2016_05
ORD IDord-2bfe53c5b13542378e7aebc0e6562ace
Source noteuspto-grants-2016_05