Hydrochloric Acid → HCID 53233431, compound

HRID 520655Notes

Reaction equation

HRID 520655 reaction equation
C1(S([N:10]2[C:18]3[C:13](=[C:14]([NH:37][C:38]([C:40]4[O:41][CH:42]=[CH:43][CH:44]=4)=[O:39])[CH:15]=[C:16]([C:19]4[CH:24]=[CH:23][N:22]=[C:21]5[N:25](S(C6C=CC=CC=6)(=O)=O)[CH:26]=[CH:27][C:20]=45)[CH:17]=3)[CH:12]=[N:11]2)(=O)=O)C=CC=CC=1.[OH-].[Na+].Cl>CC(O)C>[NH:25]1[C:21]2=[N:22][CH:23]=[CH:24][C:19]([C:16]3[CH:17]=[C:18]4[C:13]([CH:12]=[N:11][NH:10]4)=[C:14]([NH:37][C:38]([C:40]4[O:41][CH:42]=[CH:43][CH:44]=4)=[O:39])[CH:15]=3)=[C:20]2[CH:27]=[CH:26]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68226428HCID 68226428, compound

Product 1

HCID 53233431HCID 53233431, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Conditions

Temperature
70 °C

Procedure

A solution of N-{1-(phenylsulfonyl)-6-[1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-indazol-4-yl}-2-furancarboxamide (80 mg) and 2M sodium hydroxide (2 ml) in IPA (4 ml) was stirred for 18 h at RT. The solution was heated at 70° C. for 1.5 h. The solution was cooled, neutralized with 2M HCl (aq) (2 ml) and purged with nitrogen to remove the IPA. The resulting solid was collected by filtration and dried in vacuo at 50° C. to give title compound, 30 mg.

Workup

  1. temperatureThe solution was cooled
  2. custompurged with nitrogen
  3. customto remove the IPA
  4. filtrationThe resulting solid was collected by filtration
  5. customdried in vacuo at 50° C.

Sources & evidence

ORD record
ord-2bfe53c5b13542378e7aebc0e6562ace
Source dataset
uspto-grants-2016_05
Patent number
US09326987B2

Reaction notes

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