反应详情

温度

70 °C

6-(Chloromethyl)-N-[6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazol-4-yl]-2-pyridinecarboxamide (75 mg), thiomorpholine 1,1-dioxide (25 mg) and sodium iodide (25 mg) were added to a small round-bottomed flask followed by MeCN (2 ml) and DIPEA (0.048 ml). The reaction mixture was heated at 70° C. for 18 h. The reaction was cooled to RT and the solvent was removed under a stream of nitrogen. The residue was suspended in IPA (2 ml) and 2M NaOH (aq) (1 ml) was added. The mixture was stirred at RT for 2 h, heated to 50° C. for 1 h, then cooled to RT to remain stirring overnight. The reaction was heated to 60° C. for 1 h. Then 2M NaOH (aq) (0.5 ml) was added and reaction was stirred at 60° C. for 2 h. The reaction was neutralised with 2M HCl (aq.) and the solvent was removed in vacuo. The residue was dissolved in DMSO (3 ml), filtered and purified by MDAP (method K). The product-containing fractions were evaporated under a stream of nitrogen and the residues were taken up in methanol, combined and blown down to give title compound, 24 mg.

1. temperatureThe reaction was cooled to RT
2. customthe solvent was removed under a stream of nitrogen
3. addition2M NaOH (aq) (1 ml) was added
4. temperatureheated to 50° C. for 1 h
5. temperaturecooled to RT
6. stirringto remain stirring overnight
7. temperatureThe reaction was heated to 60° C. for 1 h
8. additionThen 2M NaOH (aq) (0.5 ml) was added
9. customreaction
10. stirringwas stirred at 60° C. for 2 h
11. customthe solvent was removed in vacuo
12. dissolutionThe residue was dissolved in DMSO (3 ml)
13. filtrationfiltered
14. custompurified by MDAP (method K)
15. customThe product-containing fractions were evaporated under a stream of nitrogen