3-Amino-2-thiophenecarboxylic acid → 3-Amino-N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]thiophene-2-carboxamide

HRID 52066Notes

Reaction equation

HRID 52066 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH2:19])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:20][C:21]1[CH:25]=[CH:24][S:23][C:22]=1[C:26](O)=[O:27]>>[NH2:20][C:21]1[CH:25]=[CH:24][S:23][C:22]=1[C:26]([NH:19][CH2:18]/[CH:17]=[CH:16]\[CH2:15][O:14][C:10]1[CH:9]=[C:8]([CH2:7][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:13]=[CH:12][N:11]=1)=[O:27]

Participants

3

Reactant 2

HCID 15124973-Amino-2-thiophenecarboxylic acidHCID 136724732-Buten-1-amine, 4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-, (Z)-

Product 1

HCID 677258853-Amino-N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]thiophene-2-carboxamideYield 40%

Procedure

Following a procedure similar to that described in Example 13, but using 4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenylamine and 3-amino-2-thiophenecarboxylic acid as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as colorless needles, melting at 138°-140° C., in a 40% yield.

Sources & evidence

ORD record
ord-2ff5e08e4757460e866295e82ae7c048
Source dataset
uspto-grants-1997_04
Patent number
US05616579

Reaction notes

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