HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-2-thiophenecarboxylic acid → 3-Amino-N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-2-thiophenecarboxylic acid | HCID 1512497 | — |
| Reactant | 2-Buten-1-amine, 4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-, (Z)- | HCID 13672473 | — |
| Product | 3-Amino-N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]thiophene-2-carboxamide | HCID 67725885 | 40% |
Reaction Steps
Following a procedure similar to that described in Example 13, but using 4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenylamine and 3-amino-2-thiophenecarboxylic acid as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as colorless needles, melting at 138°-140° C., in a 40% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05616579 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-2ff5e08e4757460e866295e82ae7c048 |
| Source note | uspto-grants-1997_04 |