反应详情

An amount of 53 mg (0.33 mmol) of 2-chloro-5-chloromethylpyridine dissolved in 6 mL of anhydrous acetonitrile was added to 68 mg (0.33 mmol) of 2-chloro-2,2-difluoro-N-(pyridin-2(1H)-ylidene)acetamide synthesized by the above method, following which 50 mg (0.36 mmol) of potassium carbonate was added and refluxing under heating was carried out for 1 hour. Following reaction completion, the reaction mixture was returned to room temperature then concentrated under reduced pressure. Diethyl ether was added to the concentrate, whereupon a solid separated out. The solid was collected by filtration and dried, affording the target compound in an amount of 49 mg (yield, 45%).

1. customsynthesized by the above method
2. additionwas added
3. temperaturerefluxing
4. temperatureunder heating
5. customreaction completion
6. customwas returned to room temperature
7. concentrationthen concentrated under reduced pressure
8. additionDiethyl ether was added to the concentrate, whereupon a solid
9. customseparated out
10. filtrationThe solid was collected by filtration
11. customdried
12. customaffording the target compound
13. customin an amount of 49 mg (yield, 45%)