Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

In a 100 mL round bottom flask, (S)-tert-butyl(1-(dimethylamino)-3-methyl-1-oxobutan-2-yl)carbamate S2 (4.65 g, 19.3 mmol, 1.00 equiv.) is allowed to stir with a 4.0 M solution of hydrochloric acid in dioxane (28.9 mL, 116 mmol, 6.00 equiv.) for 1.5 h at 22° C. under air, after which the solution is purged with nitrogen for 30 min (removal of HCl gas) and the solvent is removed under reduced pressure to yield (S)-2-amino-N,N,3-trimethylbutanamide as HCl salt S3, which is used without purification in the subsequent condensation.

Provenance & Evidence