反应详情

In a 100 mL round bottom flask, (S)-tert-butyl(1-(dimethylamino)-3-methyl-1-oxobutan-2-yl)carbamate S2 (4.65 g, 19.3 mmol, 1.00 equiv.) is allowed to stir with a 4.0 M solution of hydrochloric acid in dioxane (28.9 mL, 116 mmol, 6.00 equiv.) for 1.5 h at 22° C. under air, after which the solution is purged with nitrogen for 30 min (removal of HCl gas) and the solvent is removed under reduced pressure to yield (S)-2-amino-N,N,3-trimethylbutanamide as HCl salt S3, which is used without purification in the subsequent condensation.

1. customafter which the solution is purged with nitrogen for 30 min
2. custom(removal of HCl gas)
3. customthe solvent is removed under reduced pressure