1-Ethynyl-3-fluorobenzene → HCID 90031129, compound

HRID 520795Notes

Reaction equation

HRID 520795 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[CH2:11][C@H:10]3[CH2:14][CH2:15][CH2:16][C@@H:9]23)=[N:6][CH:7]=1.[C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([F:25])[CH:20]=1)#[CH:18]>>[F:25][C:21]1[CH:20]=[C:19]([C:17]#[C:18][C:2]2[CH:3]=[CH:4][C:5]([N:8]3[C:12](=[O:13])[CH2:11][C@H:10]4[CH2:14][CH2:15][CH2:16][C@@H:9]34)=[N:6][CH:7]=2)[CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 5202181-Ethynyl-3-fluorobenzeneHCID 90031855HCID 90031855, compound

Product 1

HCID 90031129HCID 90031129, compoundYield 96%

Procedure

The title compound was prepared in accordance with the general method of Example 1, step 7 using (3aR,6aR)-1-(5-iodopyridin-2-yl)hexahydro-cyclopenta[b]pyrrol-2(1H)-one (107 mg, 0.326 mmol) (Example 1, step 6) and 1-ethynyl-3-fluorobenzene to yield 100 mg (96%) of the title compound as a viscous yellow oil; MS: m/e=321.2 (M+H+).

Sources & evidence

ORD record
ord-ee7bb520f7d3424b82d3c59c40d865c8
Source dataset
uspto-grants-2016_05
Patent number
US09328090B2

Reaction notes

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