Potassium Sulfate → HCID 71570094, compound

HRID 520802Notes

Reaction equation

[ClH:1].[CH:2]1([NH:5][CH2:6][C@@H:7]2[C@H:11]([F:12])[CH2:10][N:9]([C:13]3[C:22]([O:23][CH3:24])=[C:21]4[C:16]([C:17](=[O:31])[C:18]([C:28]([OH:30])=[O:29])=[CH:19][N:20]4[CH2:25][CH2:26][F:27])=[CH:15][C:14]=3[F:32])[CH2:8]2)[CH2:4][CH2:3]1.S([O-])([O-])(=O)=O.[K+].[K+]>>[OH2:23].[ClH:1].[CH:2]1([NH:5][CH2:6][C@@H:7]2[C@H:11]([F:12])[CH2:10][N:9]([C:13]3[C:22]([O:23][CH3:24])=[C:21]4[C:16]([C:17](=[O:31])[C:18]([C:28]([OH:30])=[O:29])=[CH:19][N:20]4[CH2:25][CH2:26][F:27])=[CH:15][C:14]=3[F:32])[CH2:8]2)[CH2:3][CH2:4]1

Participants

Reactant 2

HCID 24507Potassium Sulfate

HCID 715287671433857-09-0

Product 1

HCID 71570094HCID 71570094, compound

Procedure

1 g of 7-{(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride salt (crystals A) was spread over a petri dish and placed in a desiccator in which a saturated potassium sulfate solution had been placed. The crystals A was stored at 25° C. for 1 week to obtain 7-{(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride salt hydrate (crystals B).

Workup

customplaced in a desiccator in which
waitThe crystals A was stored at 25° C. for 1 week

Sources & evidence

ORD record: ord-9c2376a72e2c441687e3ebbc4deefec1
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09328089B2

Reaction notes

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