反应详情

温度

250 °C

To a suspension of 2-amino terephthalic acid (12 g, 6.6 mmols) in diphenyl ether (120 mL), cyclohexanone (25 mL) was added and the reaction mixture was heated to 250° C. for 10 min. Reaction completion was monitored by LC/MS (75% starting material and 25% Product formation was observed). Cyclohexanone (25 mL) was added and the reaction mixture was heated to 250° C. for another 10 min. (LC/MS showed 50% product formation). The above process was repeated till LC/MS showed complete product formation (Starting material <2%). The reaction mixture was cooled to 25° C., product was filtered, washed with hexane (100 mL) and dried under vacuum to get 15.8 g of (Via) (98%) as a yellow solid.

1. additionwas added
2. customReaction completion
3. temperatureThe reaction mixture was cooled to 25° C.
4. filtrationproduct was filtered
5. washwashed with hexane (100 mL)
6. customdried under vacuum
7. customto get 15.8 g of (Via) (98%) as a yellow solid