反应详情

Propargylamine (5 mL) is added to a flask charged with a stir bar, 2-tetralone (10.00 g), NaAuCl4*2H2O (0.65 g), and ethanol (50 mL) (caution: a very exothermic reaction may evolve afterwards→keep an ice bath at hand). The resulting mixture is stirred at room temperature for 15 min and then at reflux temperature for 1 h. After cooling the mixture to room temperature, the solvent is evaporated and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 60:40) to afford the title compound as an oil. Yield: 6.78 g (56% of theory); LC (method 1): tR=1.81 min; Mass spectrum (ESI+): m/z=182 [m+H]+. Alternatively, the reaction may be conducted in a microwave oven heating with microwave irradiation to 100° C. for 10 min.

1. additioncharged with a stir bar
2. custommay evolve afterwards→keep an ice bath at hand
3. temperatureat reflux temperature for 1 h
4. temperatureAfter cooling the mixture to room temperature
5. customthe solvent is evaporated
6. customthe residue is chromatographed on silica gel (cyclohexane/ethyl acetate 60:40)