Acetic Anhydride → N-[5-(4-Piperidinomethyl-2-pyridyloxy)pentyl]-2-(2-acetoxyethylthio)acetamide

HRID 52101Notes

Reaction equation

HRID 52101 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:27])[CH2:22][S:23][CH2:24][CH2:25][OH:26])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:28](OC(=O)C)(=[O:30])[CH3:29]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:27])[CH2:22][S:23][CH2:24][CH2:25][O:26][C:28](=[O:30])[CH3:29])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 19962903N-[5-(4-Piperidinomethyl-2-pyridyloxy)pentyl]-2-(2-hydroxyethylthio)acetamide

Product 1

HCID 19962959N-[5-(4-Piperidinomethyl-2-pyridyloxy)pentyl]-2-(2-acetoxyethylthio)acetamideYield 90%

Procedure

Following a procedure similar to that described in Example 67(c), but using N-[5-(4-piperidinomethyl-2-pyridyloxy)pentyl]-2-(2-hydroxyethylthio)acetamide [prepared as described in step (a) above] and acetic anhydride as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as an oil in a 90% yield.

Sources & evidence

ORD record
ord-2e06c20db61040b698673f159290e624
Source dataset
uspto-grants-1997_04
Patent number
US05616579

Reaction notes

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