Methylamine → HCID 178485263, compound

HRID 521117Notes

Reaction equation

[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:12]3[CH2:17][CH2:16][CH2:15][C@@H:14]4[C:18]5[CH:19]=[CH:20][C:21]([C:25](O)=[O:26])=[CH:22][C:23]=5[CH2:24][C@H:13]34)=[O:11])=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:28][NH2:29]>>[CH3:28][NH:29][C:25]([C:21]1[CH:20]=[CH:19][C:18]2[C@@H:14]3[C@@H:13]([N:12]([C:10]([C:8]4[CH:7]=[CH:6][C:5]5[NH:1][CH:2]=[N:3][C:4]=5[CH:9]=4)=[O:11])[CH2:17][CH2:16][CH2:15]3)[CH2:24][C:23]=2[CH:22]=1)=[O:26]

Participants

Reactant 2

HCID 6329Methylamine

HCID 178524092HCID 178524092, compound

Product 1

HCID 178485263HCID 178485263, compoundYield 19%

Procedure

The title compound is prepared from cis-1-(1H-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine-7-carboxylic acid and methylamine (2 mol/L in tetrahydrofuran) following a procedure analogous to that described in Example 1. Yield: 19% of theory; LC (method 1): tR=1.86 min; Mass spectrum (ESI+): m/z=375 [M+H]+.

Sources & evidence

ORD record: ord-7db90da7c82444469fc0c44961a8f8c5
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09328072B2

Reaction notes

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