Hydrochloric Acid → HCID 86729385, compound

HRID 521223Notes

Reaction equation

HRID 521223 reaction equation
[C:1]([C:4]1[C:5]([NH:25][C:26]2[CH:27]=[N:28][CH:29]=[C:30]([F:32])[CH:31]=2)=[N:6][N:7]([C:9]2([CH2:22][C:23]#[N:24])[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH:8]=1)(=[O:3])[NH2:2].[ClH:33]>O1CCOCC1>[Cl-:33].[C:1]([C:4]1[C:5]([NH:25][C:26]2[CH:27]=[N:28][CH:29]=[C:30]([F:32])[CH:31]=2)=[N:6][N:7]([C:9]2([CH2:22][C:23]#[N:24])[CH2:10][CH2:11][NH2+:12][CH2:13][CH2:14]2)[CH:8]=1)(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86729387HCID 86729387, compound

Product 1

HCID 86729385HCID 86729385, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 4-(4-carbamoyl-3-(5-fluoropyridin-3-ylamino)-1H-pyrazol-1-yl)-4-(cyanomethyl)piperidine-1-carboxylate (Example 13-14) (305 mg, 0.688 mmol) was dissolved in 4 M HCl in 1,4-dioxane (7 mL). The resulting solution was maintained at ambient temperature for 2 hours. The mixture was then concentrated in vacuo to afford the title compound, Intermediate #39.

Workup

  1. concentrationThe mixture was then concentrated in vacuo

Sources & evidence

ORD record
ord-6f4cd4a80e934d91a2d2d39dcad96750
Source dataset
uspto-grants-2016_05
Patent number
US09328099B2

Reaction notes

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