4-Chlorobutyryl chloride → N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-chlorobutyramide

HRID 52126Notes

Reaction equation

HRID 52126 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH2:19])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:20][CH2:21][CH2:22][CH2:23][C:24](Cl)=[O:25]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:24](=[O:25])[CH2:23][CH2:22][CH2:21][Cl:20])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 783704-Chlorobutyryl chlorideHCID 136724732-Buten-1-amine, 4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-, (Z)-

Product 1

HCID 67726214N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-chlorobutyramideYield 73%

Procedure

Following a procedure similar to that described in Preparation 1, but using 4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenylamine and 4-chlorobutyryl chloride as starting materials, in relative proportions similar to those used in that Preparation, the title compound was obtained at a yield of 73%.

Workup

  1. customthat described in Preparation 1
  2. customin relative proportions similar to those used in that Preparation

Sources & evidence

ORD record
ord-f7c8754445f445d090373594a3ffea04
Source dataset
uspto-grants-1997_04
Patent number
US05616579

Reaction notes

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