Hydrochloric Acid → HCID 58837347, compound

HRID 521310Notes

Reaction equation

HRID 521310 reaction equation
[CH3:1][C:2]([CH3:28])([CH2:21][C:22]1([CH3:27])OCC[O:23]1)[CH2:3][N:4]1[C:16]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[C:8]([NH2:17])[C:7]=2[N:6]=[C:5]1[CH2:18][CH2:19][CH3:20].Cl>>[NH2:17][C:8]1[C:7]2[N:6]=[C:5]([CH2:18][CH2:19][CH3:20])[N:4]([CH2:3][C:2]([CH3:28])([CH3:1])[CH2:21][C:22](=[O:23])[CH3:27])[C:16]=2[C:15]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:9]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 58837327HCID 58837327, compound

Product 1

HCID 58837347HCID 58837347, compound

Procedure

By the general method of Example 11, 1-[2,2-dimethyl-3-(2-methyl-[1,3]dioxolan-2-yl)propyl]-2-propyl-1H-imidazo[4,5-c]quinolin-4-amine was hydrolyzed with aqueous hydrochloric acid to provide 5-(4-amino-2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)-4,4-dimethylpentan-2-one as a light brown solid after recrystallization from aqueous acetonitrile, mp 178-180° C.

Sources & evidence

ORD record
ord-b6c597bd70eb45a59710b27685a507ae
Source dataset
uspto-grants-2016_05
Patent number
US09328110B2

Reaction notes

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