反应详情

温度

100 °C

43 g of ammonia are injected into an autoclave with a solution of 40.2 g (122 mmol) of N,N-diethyl-3-(diethylcarbamoylthio)-2-fluoronicotinamide in 350 g of methanol, and the mixture is heated at 100° C. for 10 hours. It is then concentrated in vacuo and chromatographed on silica gel using ethyl acetate. Subsequent recrystallization from Et2O/hexane gives 18.7 g (47%) of yellowish crystals.

1. concentrationIt is then concentrated in vacuo
2. customchromatographed on silica gel
3. customSubsequent recrystallization from Et2O/hexane