Ammonia → HCID 19963244, compound

Participants

Reaction Conditions

Reaction Steps

43 g of ammonia are injected into an autoclave with a solution of 40.2 g (122 mmol) of N,N-diethyl-3-(diethylcarbamoylthio)-2-fluoronicotinamide in 350 g of methanol, and the mixture is heated at 100° C. for 10 hours. It is then concentrated in vacuo and chromatographed on silica gel using ethyl acetate. Subsequent recrystallization from Et2O/hexane gives 18.7 g (47%) of yellowish crystals.

Provenance & Evidence