Potassium Iodide → 2,3-dimethyl-4-(2-morpholinoethylthio)pyridine-N-oxide

HRID 52136Notes

Reaction equation

HRID 52136 reaction equation
Cl[CH2:2][CH2:3][S:4][C:5]1[CH:10]=[CH:9][N+:8]([O-:11])=[C:7]([CH3:12])[C:6]=1[CH3:13].C(=O)([O-])[O-].[K+].[K+].[I-].[K+].[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>CN(C)C=O.C1(C)C=CC=CC=1>[CH3:12][C:7]1[C:6]([CH3:13])=[C:5]([S:4][CH2:3][CH2:2][N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[CH:10]=[CH:9][N+:8]=1[O-:11]

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 8083MorpholineHCID 11430Potassium CarbonateHCID 199630384-(2-Chloroethylthio)-2,3-dimethylpyridine-N-oxide

Product 1

HCID 199631002,3-dimethyl-4-(2-morpholinoethylthio)pyridine-N-oxide

Reagents, catalysts & solvents 1

HCID 21735183Dimethylformamide tolueneSolvent

Procedure

4-(2-Chloroethylthio)-2,3-dimethylpyridine-N-oxide (6 g) was dissolved in a mixed solution of dimethylformamide-toluene (1:1) and thereto were added potassium carbonate (4.3 g), potassium iodide (4.4 g) and morpholine (1.9 ml). The mixture was reacted at 50-55° C. for 12 hours. After the completion of the reaction, inorganic matters were filtered off and the solvent was distilled away. Water was added to the residue and the mixture was extracted with chloroform. After drying over anhydrous magnesium sulfate, the chloroform was distilled away and the obtained residue was purified by silica gel column chromatography to give 3.4 g of 2,3-dimethyl-4-(2-morpholinoethylthio)pyridine-N-oxide.

Workup

  1. customThe mixture was reacted at 50-55° C. for 12 hours
  2. customAfter the completion of the reaction, inorganic matters
  3. filtrationwere filtered off
  4. distillationthe solvent was distilled away
  5. additionWater was added to the residue
  6. extractionthe mixture was extracted with chloroform
  7. dry with materialAfter drying over anhydrous magnesium sulfate
  8. distillationthe chloroform was distilled away
  9. customthe obtained residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-d7f66b475d3b4a4dade481eadc6048e4
Source dataset
uspto-grants-1997_04
Patent number
US05616581

Reaction notes

Loading…