Hydrazine hydrate (1:1) → HCID 178431729, Verbindung

HRID 521424Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 521424
[CH3:1][C:2]1([C:5]([N:7]2[CH2:16][C:15]3[NH:14][C:13]4[CH:17]=[CH:18][CH:19]=[C:20]([C:21]([O:23]C)=O)[C:12]=4[C:11](=O)[C:10]=3[CH2:9][CH2:8]2)=[O:6])[CH2:4][CH2:3]1.O.[NH2:27][NH2:28]>>[CH3:1][C:2]1([C:5]([N:7]2[CH2:16][C:15]3[NH:14][C:13]4[CH:17]=[CH:18][CH:19]=[C:20]5[C:21](=[O:23])[NH:27][N:28]=[C:11]([C:12]=45)[C:10]=3[CH2:9][CH2:8]2)=[O:6])[CH2:4][CH2:3]1

Komponenten

3

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 89657592Methyl 2-(1-methylcyclopropanecarbonyl)-5-oxo-1,2,3,4,5,10-hexahydrobenzo[b][1,7]naphthyridine-6-carboxylate

Produkt 1

HCID 178431729HCID 178431729, Verbindung

Versuchsvorschrift

The target product was prepared from methyl 2-(1-methylcyclopropanecarbonyl)-5-oxo-1,2,3,4,5,10-hexahydrobenzo[b][1,7]naphthyridine-6-carboxylate and hydrazine hydrate according to the same procedure described as in Example 1 (step 4). 1H NMR (DMSO-d6) δ 11.8 (s, 1H), 10.6 (s, 1H), 7.62-7.64 (m, 1H), 7.47-7.49 (m, 1H), 7.24-7.26 (m, 1H), 4.41 (bs, 2H), 3.85 (bs, 2H), 2.42 (bs, 2H), 1.28 (s, 3H), 0.84 (bs, 2H), 0.60 (bs, 2H). MS (ESI) m/e [M+1]+323.

Quellen und Nachweise

ORD-Eintrag
ord-2c9fa73ab56c42a3a731f2e24bacf65c
Quelldatensatz
uspto-grants-2016_05
Patentnummer
US09328111B2

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