Hydrazine hydrate (1:1) → HCID 178518772, compound

HRID 521428Notes

Reaction equation

HRID 521428 reaction equation
[CH2:1]([N:8]1[CH2:17][C:16]2[NH:15][C:14]3[CH:18]=[CH:19][CH:20]=[C:21]([C:22]([O:24]C)=O)[C:13]=3[C:12](=O)[C:11]=2[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:28][NH2:29]>>[CH2:1]([N:8]1[CH2:9][C:10]2[NH:15][C:14]3[CH:18]=[CH:19][CH:20]=[C:21]4[C:22](=[O:24])[NH:28][N:29]=[C:12]([C:13]=34)[C:11]=2[CH2:16][CH2:17]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 121297550Methyl 2-benzyl-5-oxo-1,2,3,4,5,10-hexahydrobenzo[b][1,7]naphthyridine-6-carboxylate

Product 1

HCID 178518772HCID 178518772, compound

Procedure

Example 18 was prepared from methyl 2-benzyl-5-oxo-1,2,3,4,5,10-hexahydrobenzo[b][1,7]naphthyridine-6-carboxylate and hydrazine hydrate according to the same procedures described as those in Example 15. 1H NMR (DMSO-d6) δ 8.37 (s, 1H), 7.21-7.56 (m, 8H), 3.81 (s, 2H), 3.39 (s, 2H), 2.91 (t, 2H, J=8.4 Hz), and 2.25 (t, 2H, J=8.4 Hz). MS (ESI) m/e [M+1]+ 331.0.

Sources & evidence

ORD record
ord-10307281b8664113baaf92275af8f86d
Source dataset
uspto-grants-2016_05
Patent number
US09328111B2

Reaction notes

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