反应详情

The compound of step 1 (0.50 g, 1.43 mmol) was dissolved in dioxane (5 ml), lithium hydroxide (7.1 ml of an aqueous 1 M (i.e. 1 mol per liter) solution) was added, and the mixture was reacted overnight. The mixture was partitioned between 2 N hydrochloric acid and EA, the aqueous phase extracted with EA, and the organic extracts were dried over sodium sulfate, filtered and evaporated to dryness in vacuo to give 0.414 g of the title compound.

1. customthe mixture was reacted overnight
2. customThe mixture was partitioned between 2 N hydrochloric acid and EA
3. extractionthe aqueous phase extracted with EA
4. dry with materialthe organic extracts were dried over sodium sulfate
5. filtrationfiltered
6. customevaporated to dryness in vacuo