反应详情

The compound of example 1 (60 mg, 0.118 mmol) was dissolved in dioxane (1.5 ml), lithium hydroxide (0.59 ml of an aqueous 1 M solution) was added and the mixture was reacted for 20 min at 60° C. The mixture was partitioned between 2 N hydrochloric acid and EA, the aqueous phase extracted with EA, and the organic extracts were dried over sodium sulfate, filtered and evaporated to dryness in vacuo. The residue was stirred overnight with a mixture of diethyl ether and HEP, filtered, and the solid was dried in vacuo to give 43 mg of the title compound.

1. customthe mixture was reacted for 20 min at 60° C
2. customThe mixture was partitioned between 2 N hydrochloric acid and EA
3. extractionthe aqueous phase extracted with EA
4. dry with materialthe organic extracts were dried over sodium sulfate
5. filtrationfiltered
6. customevaporated to dryness in vacuo
7. filtrationfiltered
8. customthe solid was dried in vacuo