1-(3-Methylphenyl)cyclopropane-1-carbonitrile → m-Methylphenylacetonitrile

HRID 521445Notes

Reaction equation

HRID 521445 reaction equation
[C:1]1([CH3:12])[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([C:10]#[N:11])CC2)[CH:2]=1>CC(=O)OCC>[C:1]1([CH3:12])[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:10]#[N:11])[CH:2]=1

Participants

3

Reactant 1

HCID 200261921-(3-Methylphenyl)cyclopropane-1-carbonitrile

Product 1

HCID 76279m-Methylphenylacetonitrile

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

After silica gel chromatography of the residue (HEP/EA gradient), an approximately 1:1 mixture of 1-m-tolyl-cyclopropanecarbonitrile and the starting compound m-tolylacetonitrile was obtained.

Sources & evidence

ORD record
ord-3530f22246634abb9fe503f7d114cf3c
Source dataset
uspto-grants-2016_05
Patent number
US09328071B2

Reaction notes

Loading…