methyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate hydrochloride → HCID 67076726, compound

HRID 521500Notes

Reaction equation

HRID 521500 reaction equation
CO[C:3](=[O:13])[C:4]1[CH:9]=[C:8]([Br:10])[C:7]([O:11][CH3:12])=[N:6][CH:5]=1.Cl.[CH3:15][O:16][C:17]([C:19]1([NH2:28])[CH2:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20]1)=[O:18]>>[CH3:15][O:16][C:17]([C:19]1([NH:28][C:3]([C:4]2[CH:5]=[N:6][C:7]([O:11][CH3:12])=[C:8]([Br:10])[CH:9]=2)=[O:13])[CH2:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20]1)=[O:18]

Participants

3

Reactant 2

HCID 45074056methyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate hydrochlorideHCID 46311221Methyl 5-bromo-6-methoxypyridine-3-carboxylate

Product 1

HCID 67076726HCID 67076726, compound

Procedure

5-Bromo-6-methoxy-nicotinic acid methyl ester (W. J. Thompson and J. Gaudino, J. Org. Chem. 49 (1984), 5237-5243) (2.00 g, 8.13 mmol) was hydrolyzed in analogy to example 2. The obtained acid was reacted with 2-amino-indane-2-carboxylic acid methyl ester hydrochloride in analogy to step 2 of example 13.

Sources & evidence

ORD record
ord-e51061dfa85b486786ee72748256699a
Source dataset
uspto-grants-2016_05
Patent number
US09328071B2

Reaction notes

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